AIMS To analyse the associations between DUP and long-term outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. Marshall M, Lewis S, Lockwood A, et al . Previous studies have associated a longer DUP with a poor prognosis, but few of them were performed in countries with low and middle level of income. AIM: Duration of untreated psychosis (DUP) is considered as a key prognostic variable in psychosis. Am J Psychiatry. This presentation was delivered by Jo Smith at the Worcestershire Early Intervention Service Study day, 9th June 2011. DUP is generally determined as the time from the onset of psychotic symptoms to the initiation of treatment or first clinical presentation, when a diagnosis of first-episode psychosis may be given. Association between duration of untreated psychosis and in cohorts of first-episode outcome patients: a systematic review. In general, research has shown that treatments for psychosis work better when they are delivered closer to the time … 1 One key strategy is reducing the duration of untreated psychosis (DUP), the time from the first symptom of psychosis to the start of treatment. Free Online Library: Duration of untreated psychosis and clinical outcomes of first-episode schizophrenia: a 4-year follow-up study. We systematically reviewed the literature on racial and ethnic differences in DUP in patients with FEP. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis - Volume 205 Issue 2 - Matti Penttilä, Erika Jääskeläinen, Noora Hirvonen, Matti Isohanni, Jouko Miettunen est association between DUP and outcome, which sup-ports the case for clinical trials that examine the effect of reducing DUP. Studies performed to assess the relevance of duration of untreated psychosis (DUP) as a predictor of long-term outcome (i.e. follow-ups of ten years or more) are somewhat limited. U2 - 10.1001/archpsyc.62.9.975. This study by Addington et al provides another substantial advance in the burgeoning literature on the importance of the duration of untreated psychosis (DUP) in relation to outcomes in the early course of schizophrenia. Bradford DW, Perkins DO, Lieberman JA. Duration of Untreated Psychosis (DUP) is commonly defined as the time interval between onset of definite positive psychotic symptoms and first appropriate treatment. “Larger longitudinal studies of longer duration are needed to examine the association between [duration of untreated psychosis], hippocampal volume and clinical outcomes.” – by Savannah Demko To assess the impact of duration of untreated psychosis (DUP) on baseline and 18-month follow-up characteristics controlling for relevant confounders in an epidemiological first-episode psychosis (FEP) cohort.The Early Psychosis Prevention and Duration of untreated psychosis (DUP) is one of the few potentially modifiable outcome predictors in psychosis. DUP is also known to be longer in lower- and middle-income countries. Duration of untreated psychosis and outcomes What is duration of untreated psychosis (DUP)? For over a decade, the DUP has been studied as a potential predictor of a variety of outcomes. Duration of untreated psychosis (DUP), defined as delay in treatment with antipsychotic medication, was found to be associated with an unfavorable course of schizophrenia. 2005;162(10):1785-1804. Figure 1 shows the differences in access to mental 2 The Canadian Journal of Psychiatry -To reduce duration of untreated psychosis (DUP), which has been associated with worse outcomes … DO - 10.1001/archpsyc.62.9.975 METHODS: Data from 2 cohorts of patients with first episode psychosis … An extended duration of untreated psychosis (DUP) is associated with poor outcome in first-episode psychosis (FEP). 2005;62:975-983 URATION OF UNTREATED psychosis (DUP) is de-fined as the time from manifestationofthefirst psychotic symptom to initiation of adequate antipsychotic drug treatment. BACKGROUND Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Duration of untreated psychosis (DUP) is the time between onset of psychotic symptoms and initiation of antipsychotic medication. 2. What is the duration of untreated psychosis (DUP)? Studies have shown that the earlier treatment is initiated for psychosis, the better the long-term outcomes for the patient. Objective: The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. Untreated psychosis has long been associated with worse clinical outcomes in patients with schizophrenia. We searched electronic databases and conducted forward … Methodologically sound studies that have examined the association of DUP and outcome of schizophrenia in these countries are lacking. Perkins DO, Gu H, Boteva K, et al. by Marshall and colleagues (2) of DUP and outcomes among patients with FEP. Delay in intensive psychosocial treatment (DIPT) may also be related to outcome. This study examined outcome and factors related to it after one year of treatment of schizophrenia patients who were ill for many years and not previously treated. Context : Longer duration of untreated psychosis (DUP) is known to be associated with poorer outcome of schizophrenia. There is a requirement for services to reduce the duration of untreated psychosis, as this has been shown to be associated with better long-term outcomes. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. If so, outcome might be improved through earlier detection and treatment. Yet, it is unclear whether a longer DUP causes worse outcomes or whether reported associations have alternative explanations. 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duration of untreated psychosis and outcome

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